Ctcf myc

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August undefined, 2024

WebJan 10, 2003 · The understanding of MYC regulation by CTCF noted above suggested that CTCF induction, repressing MYC transcription, might be pivotal to growth arrest and apoptosis in immature B cells. Here, we … WebAug 7, 2024 · CTCF is a multi-functional protein involved in various cellular processes, including transcription repression and insulation [ 20 ]. In particular, this protein was initially identified as a...

MYC reshapes CTCF-mediated chromatin architecture in prostate …

WebApr 4, 2024 · Perturbation of the Core CTCF Motif in the MYC CTCF Loop-Anchor Reduces CTCF Occupancy and MYC Expression (A) Schematic representation of the experiment. HCT-116, K562, Jurkat, and MCF7 cells were transduced with a construct expressing MYC under a PGK promoter and selected for successful integration. WebJun 28, 2024 · CCCTC-binding factor (CTCF) was first identified as a nuclear DNA-binding protein, which negatively regulates chicken c-myc expression by interacting with three regularly spaced repeats of the CCCTC DNA motif . Since then, considerable attention has been focused on CTCF leading to pivotal discoveries related to its structure, binding … how did rulers of axum gain power and wealth

Acute depletion of CTCF rewires genome-wide chromatin …

WebCommunicate with your doctor Get answers to your medical questions from the comfort of your own home Access your test results No more waiting for a phone call or letter – view your results and your doctor's comments within days WebTranscriptional activation of MYC is a hallmark of many B cell lineage neoplasms. MYC provides a constitutive proliferative signal but can also initiate ARF-dependent activation of p53 and apoptosis. The E3 ubiquitin … WebDec 31, 2014 · this project studies the regulatory and functional interaction of myc and ctcf transcription factors in normal hematopoyetica differentiation and in haematologic neoplasms. myc is a deregulated oncogenic transcription factor in more than half of human tumors, and is prevalent in lymphomas, where it is associated with progression. how did rugby originate

DLGAP1-AS2 promotes human colorectal cancer progression

Recombinant Human CTCF protein (ab153114) Abcam

WebThe Myc-associated zinc finger protein (MAZ) is often found at genomic binding sites adjacent to CTCF, a protein which affects large-scale genome organization through its interaction with cohesin. We show here that, like CTCF, MAZ physically interacts with a cohesin subunit and can arrest cohesin sliding independently of CTCF. WebApr 14, 2024 · Numerous studies have shown that CTCF regulates enhancer–promoter interactions and the human genome contains thousands of CTCF binding sites [40,41]. Transcription of eRNA may represent a common mechanism allowing neighboring genes to be differentially regulated. ... Although MYC overexpression has long been known to … how many spanish settlers came to americaWebJul 1, 2009 · Moreover, deletion of the CTCF site at the MYC P2 promoter reduces transcription but does not affect promoter acetylation or serum-inducible transcription. … how many spanish people are in america

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Ctcf myc

Acute depletion of CTCF directly affects MYC regulation

WebApr 1, 2024 · Cell-Type-Specific Super-Enhancers in the MYC Locus Loop to a Common CTCF Site (A) The 4.5 Mb region surrounding the MYC gene. The 2.8 Mb TAD containing MYC and portions of the two adjacent TADs ... WebCTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic contexts. CTCF was first isolated and cloned on the …

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WebSep 29, 2014 · CTCF, which is known for its role as chromatin organiser, is thought to be involved in the activation of C-MYC expression. The affinity of CTCF to its binding site on the DNA is negatively... WebProtein Recombinant Human DUSP6 protein (ab183239) View more associated products Description Product name Recombinant Human CTCF protein See all CTCF proteins and peptides Expression system Wheat germ Protein length Full length protein Animal free No Nature Recombinant Species Human Sequence

WebThe Myc-associated zinc finger protein (MAZ) is often found at genomic binding sites adjacent to CTCF, a protein which affects large-scale genome organization through its … WebJul 26, 2024 · Whole transcriptome analysis showed hundreds of genes differentially expressed in CTCF-depleted cells, among which MYC and a number of MYC target …

WebTranscriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the … WebCREs-MYC interaction, methylation of the CTCF sites contributed to greater risks in prostate cancer [63].CRISPR inactivation screens in metastatic prostate cancer cell lines LNCaP, C42B detected ...

WebSep 29, 2014 · Here, the copy number of C-MYC of five different prostate cancer cell lines has been determined by FISH, and the state of methylation of the binding site of CTCF …

Websequencing of NeP1 showed it to be CTCF (Ref. 10) and thus identified a new AT-rich CTCF target site in the lysozyme silencer that is markedly dissimilar with GC-rich target sites in MYC. In two subsequent, independent studies, proteins binding to the APP β site of the human amyloid precursor protein (APP) how many spanish people live in usWebOct 12, 2024 · DLGAP1-AS2 directly binds to CTCF and activates Myc transcription. Given that CTCF is a key regulator of Myc, we then tested whether CTCF is involved in DLGAP1-AS2-mediated Myc regulation. As shown in Fig. 5A, silencing of … how did rulers consolidate power in europeWebJun 23, 2024 · In addition to well-known universal functions of chromosomal CTCF (and to a lesser known centrosomal CTCF functions) expressed … how many spanish ships returned to spainWebApr 13, 2024 · MYC is a well characterized oncogenic transcription factor in prostate cancer, and CTCF is the main architectural protein of three-dimensional genome organization. However, the functional link between the two master regulators has not been reported. In this study, we find that MYC rewires prostate ... how many spanish letters are thereWebAug 24, 2024 · For instance, MYC, a well-characterized CTCF co-regulatory partner , showed a profound decrease at the mRNA and protein levels following CTCF loss, and its downstream genes were also the most significantly downregulated after IAA treatment (enrichment FDR < 1 × 10 –72 at 24 h, and FDR < 1 × 10 −178 at 48 h). Moreover, … how many spanish people in usWebMyc is a family of regulator genes and proto-oncogenes that code for transcription factors. Gene expression of CTCF in human cancer cells and control uncover the disrupted enhancer-promoter regulation of MYC in human cancer cells. Overall design: RNA-seq library constructed on genome wide deletion of CTCF cells and control. Contributor(s) how many spanish in uaeWebMay 1, 2009 · CTCF is a ubiquitous transcription factor that is involved in numerous, seemingly unrelated functions. These functions include, but are not limited to, positive or negative regulation of transcription, enhancer-blocking activities at developmentally regulated gene clusters and at imprinted loci, and X-chromosome inactivation. Here, we … how many spanish flu deaths