WebOct 29, 2024 · ACOD1 is a highly conserved gene that encodes an enzyme that catalyzes the decarboxylation of cis-aconitate to itaconic acid. Itaconic acid inhibits isocitrate lyase, a key enzyme of the glyoxylate shunt, a pathway essential for bacterial growth in macrophages ( Michelucci et al., 2013 ). Cloning and Expression WebMar 15, 2024 · Download Citation IRG1/Itaconate induces metabolic reprogramming to suppress ER-positive breast cancer cell growth Most breast cancers are estrogen receptor (ER)-positive, targeted by ...
ACOD1 in immunometabolism and disease Cellular
WebJun 29, 2024 · The IRF family, which consists of nine members in mammals, plays an important role in the regulation of immune responses by producing type I IFN and … WebJul 15, 2024 · ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in response to toll-like receptor (TLR) signaling. simple walkway ideas
ACOD1 in immunometabolism and disease Cellular
WebListed are ELISA Kits for the detection of IRG1, an alias name of aconitate decarboxylase 1. The human protein, encoded by the gene ACOD1, is 481 amino acid residues long and has a mass of 52,628 daltons. It is a member of the PrpD family. This protein is reported to have a mitochondrial cellular localization. WebJun 2, 2024 · Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism Download PDF Your … WebFeb 26, 2024 · Also known as CAD; Irg1 Summary Enables aconitate decarboxylase activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of defense response; and negative regulation of signal transduction. Acts upstream of or within response to lipopolysaccharide. Located in mitochondrion. ray j mother