WebMarginal zone (MZ) B cells are derived from ‘conventional’ B2 cells and are characterized by high surface density of complement receptor 2 (CD21) and IgM [196]. These cells are … Marginal zone B cells (MZ B cells) are noncirculating mature B cells that in humans segregate anatomically into the marginal zone (MZ) of the spleen and certain other types of lymphoid tissue. The MZ B cells within this region typically express low-affinity polyreactive B-cell receptors (BCR), high levels of IgM, Toll … See more The spleen's marginal zone contains multiple subtypes of macrophages and dendritic cells interlaced with the MZ B cells; it is not fully formed until 2 to 3 weeks after birth in rodents and 1 to 2 years in humans. In … See more Similar to B1 B cells, MZ B cells can be rapidly recruited into the early adaptive immune responses in a T cell-independent manner. The MZ B … See more Many of MZ B cell-receptors are self-reactive, which may be a factor that contributes to their expansion in some autoimmune diseases. … See more In humans the splenic marginal zone B cells have evidence of somatic hypermutation in their immunoglobulin genes, indicating … See more Marginal zone B cells are the malignant cells in marginal zone lymphomas, a heterogeneous group of generally indolent lymphomas. See more
AKT activity orchestrates marginal zone B cell ... - ScienceDirect
WebMar 2, 2011 · We describe seven patients with mantle cell lymphoma that displays a biphasic histology resembling marginal-zone B-cell lymphoma. Besides typical mantle lymphoma cells, the cases showed distinct areas with larger, monocytoid cells. The latter feature is rare in mantle cell lymphoma and only 15 similar cases have previously been … harri verkkoperä
Putative role of marginal zone B cells in pathophysiological …
WebHere we identified neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell-independent immunoglobulin responses to circulating antigen. … WebAbstract: Splenic marginal zone lymphoma is a distinct low grade B-cell lymphoma primarily occurring in the spleen and separate from nodal marginal zone lymphoma and extranodal … WebAbstract: Splenic marginal zone lymphoma is a distinct low grade B-cell lymphoma primarily occurring in the spleen and separate from nodal marginal zone lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. It is characterized by a relative indolent course, splenomegaly, moderate lymphocytosis, and an ... pulp vitality testing