Paracellin 1
WebClaudin 16 (also termed paracellin 1) is a 305-aa protein with four transmembrane domains and intracellular amino and carboxyl terminals that is expressed within the intercellular … WebA new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the hypomagnesemia hypercalciuria syndrome (HHS).
Paracellin 1
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WebDec 1, 2003 · Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalcinosis. S. Weber, L. Schneider, +14 authors M. Konrad Medicine, Biology Journal of the American Society of Nephrology : JASN 2001 TLDR WebJan 1, 2002 · Paracellin-1 expression was restricted to distal tubular segments including the thick ascending limb of Henle's loop, the distal tubule, and the collecting duct. The identification and...
WebCLDN16 codes for paracellin-1, a member of the claudin family. More than 20 claudins identified so far comprise a family of ∼22 kD proteins with four transmembrane segments, two extracellular domains, and intracellular N and C termini. WebNov 1, 2006 · Paracellin-1 (claudin-16) is a renal tight junction protein encoded by the CLDN16 gene [].It is a key player in magnesium and calcium reabsorption in the thick ascending limb of Henle’s loop [].Mutations in CLDN16 gene lead to familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) [2–4], a rare …
Webtermed paracellin-1 (PCLN-1), was determined (14) and sequence analysis showed that it en-codes a protein of 305 amino acids (Fig. 2A) with four transmembrane domains and intracel-lular NH 2 - and COOH-termini (11, 15). The PCLN-1 protein shows sequence and struc-tural similarity to members of the claudin family (Fig. 2A) (15, 16) and is the most Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg 2+ Resorption David B. Simon, Yin Lu , Keith A. Choate, Heino Velazquez, [...], and Richard P. Lifton +9 authors Authors Info & Affiliations Science 2 Jul 1999 Vol 285, Issue 5424 pp. 103 - 106 DOI: 10.1126/science.285.5424.103 Abstract Supplementary Material
WebFeb 13, 2007 · Paracellin-1 is a tight junction protein, which regulates the paracellular Mg 2+ transport in the TAL. We hypothesize that CsA reduces the expression and function of paracellin-1 and accounts for the observed renal Mg 2+ wasting. Methods.
WebNov 1, 2005 · Paracellin-1 is a member of the tight junction claudin protein family and mutations in the paracellin-1 gene cause a human hereditary disease, familial … sake cafe magazine street new orleansWebTwenty years ago, the seminal work of Lifton’s group described mutations in a gene coding for a TJ protein (initially named paracellin-1 and thereafter classified as claudin-16) as being causative for a human disorder (FHHNC) . things for kids to do near me freeWebBACKGROUND: A new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of … things for kids to do near me indianapolisWebClaudin-16 (UniProt: Q9Y5I7; also known as Paracellin-1, PCLN-1) is encoded by the CDLN1 (also known as PCLN1) gene (Gene ID: 10686) in human. Claudin-16 is a multi-pass membrane protein that span the plasma membrane 4 times, with their N- and C-termini located in the cytosol. It is selectively expressed at tight junctions of renal epithelial ... things for kids to do scotlandWebSep 15, 2000 · The paracellin-1 gene, which is the causative gene for human renal hypomagnesemia with hypercaciuria and nephrocalcinosis, encodes a tight junction protein of renal epithelial cells. things for kids to do on long car ridesWebAt this location paracellin-1 might act as selectivity filter for the paracellular movement of ions and water during stimulated secretion. Thus, both in the ducts and in the acini a paracellular transport of calcium appears possible. things for kids to do when boredWebJul 2, 1999 · There has been no direct evidence, however, for the formation of a paracellular channel by any of the known tight junction proteins. In a lovely dance between clinical and basic science, the report by Simon et al. ( 4) now reveals that paracellin-1 regulates the resorption of Mg 2+ through paracellular channels in the kidney tubule. sake cafe new orleans la