Pisosterol
WebThe structure and absolute stereochemistry of pisosterol [(22R,23S)-24-methyIene-5 α lanost - 8-ene-3β22,23-triol 22-acetate] (3), the principal colourless constituent of the mycorrhizal fungus Pisolithus tinctorius, are established by n.m.r. experiments and a single-crystal X-ray analysis of the (3,23-) diacetyl derivative (4). WebTools. β-sitosterol, a prototypical phytosterol. Phytosterols are phytosteroids, similar to cholesterol, that serve as structural components of biological membranes of plants. [1] …
Pisosterol
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WebA fluorescence in situ hybridization study in an HL60 cell line, using a locus-specific probe for C-MYC, before and after treatment with pisosterol suggests that cells that do not show a high degree of C- MYC gene amplification have a less aggressive and invasive behaviour and are easy targets for chemotherapy. The leukaemia cell line HL60 is widely used in … WebAug 1, 2007 · Pisosterol, a triterpene isolated from a Pisolithus tinctorius, has been reported to have multiple biological properties. It has been shown to strongly inhibit tumor cell …
WebDownload scientific diagram Molecular structure of pisosterol isolated from Pisolithus tinctorius from publication: Cell cycle arrest induced by Pisosterol in HL60 cells with gene amplification ... WebJan 13, 2010 · We conducted a fluorescence in situ hybridization study in an HL60 cell line, using a locus-specific probe for C-MYC, before and after treatment with pisosterol (at 0.5, 1.0 and 1.8 μg/mL), a triterpene isolated from the fungus Pisolithus tinctorius. Before treatment, 87.5% of the cells showed HSRs.
WebAfter treatment, no effects were detected at lower concentrations of pisosterol (0.5 and 1.0 microg/mL). However, at 1.8 microg/mL only 15% of the cells presented HSRs, and … WebLoop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations.
WebHowever, at 1.8 µg ml⁻¹ of pisosterol, only 33% of U343 cells and 15% of AHOL1 cells presented more than two fluorescent signals, suggesting that pisosterol blocks the cells with gene amplification. Cells that do not show a high degree of C-MYC gene amplification have a less aggressive and invasive behavior and are easy targets for ...
WebSep 12, 2024 · Possible Side Effects. The current evidence suggests that phytosterol supplements are relatively safe and well-tolerated. 5 Side effects, if any, tend to be mild and may include constipation, nausea, … dave haskell actorWebJul 1, 2004 · Pisosterol lacked activity on mouse erythrocytes as well as on the development of sea urchin eggs, but strongly inhibited the growth of all seven tumor cell lines tested, especially the leukemia ... dave harlow usgsWebA-pisosterol C33H54O4 CID 14167301 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... dave hatfield obituaryWebMar 1, 2010 · Pisosterol lacked activity on mouse erythrocytes as well as on the development of sea urchin eggs, but strongly inhibited the growth of all seven tumor cell lines tested, especially the leukemia ... dave hathaway legendsWebAug 1, 2007 · Assays for α-naphthyl acetate esterase activity indicated that pisosterol triggers differentiation towards a monocytic cell-like pathway. The antiproliferative effect … dave harvey wineWebNov 9, 2010 · We conducted a study in U343 and AHOL1 glioblastoma cell lines, before and after treatment with the triterpene pisosterol. Using fluorescence in situ hybridization analysis we showed that 72% of U343... dave harkey construction chelanWebSince the early 1950s, phytosterols have been shown to lower cholesterol absorption in animals. The average daily intake of phytosterols is in the range 150–400 mg, but to be … dave harrigan wcco radio